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Professor of the Department of Molecular Biology and Genetics A.K. Bisenbaev implemented a project to develop chimeric endolysins of bacteriophages to combat multidrug-resistant pathogens of sturgeon fish. This project is aimed at solving one of the key problems of aquaculture - bacterial infections caused by gram-negative pathogens such as Pseudomonas and Aeromonas. Endolysins are enzymes encoded by phages that have peptide glycan hydrolase activity and are therefore able to destroy the bacterial cell wall, allowing the phage to leave the host cell after replication. Unlike antibiotics and bacteriophages, bacterial strains do not develop resistance to endolysins. In the context of the rapid spread of antibiotic resistance, chimeric endolysins are a promising alternative that can destroy bacterial cells and prevent outbreaks of infections. This project addresses Sustainable Development Goals (SDGs) 14 “Preservation of marine ecosystems” and 15 “Preservation of terrestrial ecosystems”. Firstly, SDG 14 is aimed at preserving marine and freshwater ecosystems. The development of new methods for combating infections allows minimizing the use of antibiotics, which reduces the risk of water pollution and preserves the health of aquaculture populations. Secondly, the project supports SDG 15, which is related to the conservation of terrestrial ecosystems, including freshwater systems. The development of aquaculture using innovative technologies helps protect biodiversity and ensure sustainable use of natural resources. Thus, the project of Professor Bisenbaev A.K. makes a significant contribution not only to the development of aquaculture and the achievement of global sustainable development goals, helping to protect aquatic ecosystems and preserve natural resources for future generations, but also opens up prospects for the development of new drugs against bacterial infections, which can also be useful for human medicine.